gamma Catenin ist ein Gen, das durch das Symbol JUP kodiert wird. Im Allgemeinen auch bezeichnet als: Junction plakoglobin; Catenin gamma; Desmoplakin III; Desmoplakin-3; JUP; CTNNG; DP3. gamma Catenin hat eine Masse von 81.75kDa, eine Aminosäurelänge von 745, und ist an folgenden Krankheiten beteiligt: Naxos disease; Arrhythmogenic right ventricular dysplasia, familial, 12.
Wir bieten 19 antikörper gegen gamma Catenin, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus, Ratte, Rind, Huhn, Hund und Katze.
Gen- und Proteininformationen
UniProt Zusammenfassung
Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).
Entrez Zusammenfassung
This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described.
Rolle bei Krankheiten
Naxos disease: An autosomal recessive disorder characterized by the association of diffuse non-epidermolytic palmoplantar keratoderma with woolly hair and cardiac abnormalities such as dilated cardiomyopathy and arrhythmogenic right ventricular dysplasia.
Arrhythmogenic right ventricular dysplasia, familial, 12: A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.
Sequenzähnlichkeiten
Belongs to the beta-catenin family.
Posttranslationale Modifikation
May be phosphorylated by FER.
Zellort
Cell junction > Adherens junction. Cell junction > Desmosome. Cytoplasm > Cytoskeleton. Membrane.
Cytoplasmic in a soluble and membrane-associated form.
