GAK ist ein Gen, das durch das Symbol GAK kodiert wird. Es ist auch bekannt als Cyclin-G-associated kinase. GAK hat eine Masse von 143.19kDa und eine Aminosäurelänge von 1311.
Wir bieten 6 antikörper gegen GAK, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.
Entrez Zusammenfassung
In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gewebespezifität
Ubiquitous. Highest in testis.
Sequenzähnlichkeiten
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Zellort
Cytoplasm > Perinuclear region. Golgi apparatus > trans-Golgi network. Cell junction > Focal adhesion.
Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focal adhesions.
