Frizzled 10 ist ein Gen, das durch das Symbol FZD10 kodiert wird. Andere Namen sind: Frizzled-10; Fz-10; FzE7; FZD10. Frizzled 10 hat eine Masse von 65.34kDa und eine Aminosäurelänge von 581.
Wir bieten 8 antikörper gegen Frizzled 10, aufgewachsen in Kaninchen und Human, welche geeignet sind für WB, IHC, ELISA and FC mit Proben abgeleitet von Human und Maus.
Gen- und Proteininformationen
UniProt Zusammenfassung
Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).
Entrez Zusammenfassung
This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer.
Gewebespezifität
Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. Weak expression detected in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate.
Sequenzähnlichkeiten
Belongs to the G-protein coupled receptor Fz/Smo family.
Posttranslationale Modifikation
Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
