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Anti-FOXL2 Antikörper

13 Products

FOXL2 ist ein Gen, das durch das Symbol FOXL2 kodiert wird. Es ist auch bekannt als Forkhead box protein L2. FOXL2 hat eine Masse von 38.77kDa, eine Aminosäurelänge von 376, und ist an folgenden Krankheiten beteiligt: Blepharophimosis, ptosis, and epicanthus inversus syndrome; Premature ovarian failure 3.

Wir bieten 13 antikörper gegen FOXL2, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.

Gen- und Proteininformationen

UniProt Zusammenfassung
Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.
Entrez Zusammenfassung
This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Expansion of a polyalanine repeat region and other mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3.
Gewebespezifität
In addition to its expression in the developing eyelid, it is transcribed very early in somatic cells of the developing gonad (before sex determination) and its expression persists in the follicular cells of the adult ovary.
Rolle bei Krankheiten
Blepharophimosis, ptosis, and epicanthus inversus syndrome: A disorder characterized by eyelid dysplasia, small palpebral fissures, drooping eyelids and a skin fold curving in the mediolateral direction, inferior to the inner canthus. In type I BPSE (BPES1) eyelid abnormalities are associated with female infertility. Affected females show an ovarian deficit due to primary amenorrhea or to premature ovarian failure (POF). In type II BPSE (BPES2) affected individuals show only the eyelid defects.

Premature ovarian failure 3: An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
Posttranslationale Modifikation
Sumoylated with SUMO1; sumoylation is required for transcriptional repression activity.
Zellort
Nucleus.
Western Blot - Anti-FOXL2 Antibody (A83945) - Antibodies.com
(3)
Western Blot - Anti-FOXL2 Antibody (A90153) - Antibodies.com
(3)
Western Blot - Anti-FOXL2 Antibody [ARC2055] (A307530) - Antibodies.com
(2)
Western Blot - Anti-FOXL2 (phospho Ser263) Antibody (A1202) - Antibodies.com
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Produkt anzeigenRekombinant Antikörper
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Produkt anzeigenRekombinant Antikörper
FOXL2 Antibody from Signalway Antibody (36868) - Antibodies.com

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