FLI1 ist ein Gen, das durch das Symbol FLI1 kodiert wird. Andere Namen sind: Friend leukemia integration 1 transcription factor; Proto-oncogene Fli-1; Transcription factor ERGB. FLI1 hat eine Masse von 50.98kDa, eine Aminosäurelänge von 452, und ist an folgenden Krankheiten beteiligt: Ewing sarcoma; Bleeding disorder, platelet-type 21.
Wir bieten 27 antikörper gegen FLI1, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus, Ratte und Katze.
Gen- und Proteininformationen
UniProt Zusammenfassung
Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014). Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.
Entrez Zusammenfassung
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants.
Rolle bei Krankheiten
Ewing sarcoma: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
Bleeding disorder, platelet-type 21: A disorder characterized by increased bleeding tendency due to platelet dysfunction. Clinical features include epistaxis, hematomas, bleeding after tooth extraction, and menorrhagia. BDPLT21 patients may have mild to moderate thrombocytopenia.
Sequenzähnlichkeiten
Belongs to the ETS family.
