FGF19 ist ein Gen, das durch das Symbol FGF19 kodiert wird. Andere Namen sind: Fibroblast growth factor 19; FGF-19. FGF19 hat eine Masse von 24kDa und eine Aminosäurelänge von 216.
Wir bieten 3 antikörper gegen FGF19, aufgewachsen in Kaninchen und Human, welche geeignet sind für WB, ELISA and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.
Entrez Zusammenfassung
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development.
Gewebespezifität
Expressed in fetal brain, cartilage, retina, and adult gall bladder.
Sequenzähnlichkeiten
Belongs to the heparin-binding growth factors family.
