FGF13 ist ein Gen, das durch das Symbol FGF13 kodiert wird. Andere Namen sind: Fibroblast growth factor 13; FGF-13; Fibroblast growth factor homologous factor 2; FHF-2; FHF2. FGF13 hat eine Masse von 27.56kDa und eine Aminosäurelänge von 245.
Wir bieten 5 antikörper gegen FGF13, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity). Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching (By similarity). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity). May regulate voltage-gated sodium channels transport and function (PubMed:15282281). May also play a role in MAPK signaling (By similarity). Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons (By similarity).
Entrez Zusammenfassung
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked cognitive disability mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini.
Gewebespezifität
Ubiquitously expressed. Predominantly expressed in the nervous system.
Sequenzähnlichkeiten
Belongs to the heparin-binding growth factors family.
Posttranslationale Modifikation
May be phosphorylated.
Zellort
Cell projection > Filopodium. Cell projection > Growth cone. Cell projection > Dendrite. Nucleus. Cytoplasm.
Not secreted.
