ETS1 ist ein Gen, das durch das Symbol ETS1 kodiert wird. Andere Namen sind: Protein C-ets-1; p54; EWSR2. ETS1 hat eine Masse von 50.41kDa und eine Aminosäurelänge von 441.
Wir bieten 13 antikörper gegen ETS1, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion.
Entrez Zusammenfassung
This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gewebespezifität
Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney.
Sequenzähnlichkeiten
Belongs to the ETS family.
Posttranslationale Modifikation
Sumoylated on Lys-15 and Lys-227, preferentially with SUMO2; which inhibits transcriptional activity.
Zellort
Cytoplasm. Nucleus.
Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27.
