Estrogen Sulfotransferase ist ein Gen, das durch das Symbol SULT1E1 kodiert wird. Andere Namen sind: Sulfotransferase 1E1; ST1E1; EST-1; Sulfotransferase, estrogen-preferring; SULT1E1; STE. Estrogen Sulfotransferase hat eine Masse von 35.13kDa und eine Aminosäurelänge von 294.
Wir bieten 7 antikörper gegen Estrogen Sulfotransferase, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (PubMed:7779757, PubMed:11884392, PubMed:11006110). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency (PubMed:11006110, PubMed:19589875). Does not sulfonate cortisol, testosterone and dopamine (PubMed:7779757, PubMed:11006110).
Entrez Zusammenfassung
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors.
Gewebespezifität
Liver, intestine and at lower level in the kidney.
Sequenzähnlichkeiten
Belongs to the sulfotransferase 1 family.
Zellort
Cytoplasm > Cytosol.
