+1 (314) 370-6046 oderKontakt

Anti-Estrogen Receptor Antikörper

7 Products

Estrogen Receptor ist ein Gen, das durch das Symbol ESR1 kodiert wird. Andere Namen sind: ER; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1; ESR1; ESR; NR3A1. Estrogen Receptor hat eine Masse von 66.22kDa, eine Aminosäurelänge von 595, und ist an Estrogen resistance beteiligt.

Wir bieten 7 antikörper gegen Estrogen Receptor, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ICC/IF and FC mit Proben abgeleitet von Human.

Gen- und Proteininformationen

UniProt Zusammenfassung
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1.
Entrez Zusammenfassung
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.
Gewebespezifität
Widely expressed. Isoform 3 is not expressed in the pituitary gland.
Rolle bei Krankheiten
Estrogen resistance: A disorder characterized by partial or complete resistance to estrogens, in the presence of elevated estrogen serum levels. Clinical features include absence of the pubertal growth spurt, delayed bone maturation, unfused epiphyses, reduced bone mineral density, osteoporosis, continued growth into adulthood and very tall adult stature. Glucose intolerance, hyperinsulinemia and lipid abnormalities may also be present.
Sequenzähnlichkeiten
Belongs to the nuclear hormone receptor family. NR3 subfamily.
Posttranslationale Modifikation
Phosphorylated by cyclin A/CDK2 and CK1. Phosphorylation probably enhances transcriptional activity. Self-association induces phosphorylation. Dephosphorylation at Ser-118 by PPP5C inhibits its transactivation activity. Phosphorylated by LMTK3 in vitro.
Zellort
Nucleus. Cytoplasm. Cell membrane.

A minor fraction is associated with the inner membrane.
Immunohistochemistry - Anti-Estrogen Receptor Antibody [RM292] (A121298) - Antibodies.com
(2)
Produkt anzeigenRekombinant Antikörper
Western Blot - Anti-Estrogen Receptor Antibody [ER505] (A248474) - Antibodies.com
(2)
SDS-PAGE - Anti-Estrogen Receptor Antibody [ESR1/420] - BSA and Azide free (A251666) - Antibodies.com
SDS-PAGE - Anti-Estrogen Receptor Antibody [ESR1/420] (A248484) - Antibodies.com
Western Blot - Anti-Estrogen Receptor Antibody [ER505] - BSA and Azide free (A251656) - Antibodies.com
(2)
Immunohistochemistry - Anti-Estrogen Receptor Antibody - Antibodies.com (A8202)
Flow Cytometry - Anti-Estrogen Receptor Antibody - Antibodies.com (A8307)

Zeigt 1-7 von 7 Produkten

Suchfilter Hauptmenü Kontakt 0Kasse
Oben