EPX ist ein Gen, das durch das Symbol EPX kodiert wird. Andere Namen sind: Eosinophil peroxidase; EPO; EPER; EPP. EPX hat eine Masse von 81.04kDa, eine Aminosäurelänge von 715, und ist an Eosinophil peroxidase deficiency beteiligt.
Wir bieten 11 antikörper gegen EPX, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.
Entrez Zusammenfassung
This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded preproprotein is proteolytically processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a gene cluster with other peroxidase genes on chromosome 17. Mutations in this gene result in eosinophil peroxidase deficiency.
Rolle bei Krankheiten
Eosinophil peroxidase deficiency: A rare abnormality without clinical symptoms characterized by decreased or absent peroxidase activity and decreased volume of the granule matrix in eosinophils.
Sequenzähnlichkeiten
Belongs to the peroxidase family. XPO subfamily.
Zellort
Cytoplasmic granule.
Cytoplasmic granules of eosinophils.
