Epac1 ist ein Gen, das durch das Symbol RAPGEF3 kodiert wird. Andere Namen sind: Rap guanine nucleotide exchange factor 3; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; EPAC 1; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; cAMP-regulated guanine nucleotide exchange factor I; cAMP-GEFI; RAPGEF3; CGEF1; EPAC. Epac1 hat eine Masse von 103.75kDa und eine Aminosäurelänge von 923.
Wir bieten 10 antikörper gegen Epac1, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus, Ratte und Pferd.
Gen- und Proteininformationen
UniProt Zusammenfassung
Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.
Gewebespezifität
Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney.
Zellort
Endomembrane system.
