ENT1 ist ein Gen, das durch das Symbol SLC29A1 kodiert wird. Andere Namen sind: Equilibrative nucleoside transporter 1; Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; Equilibrative NBMPR-sensitive nucleoside transporter; Nucleoside transporter, es-type; Solute carrier family 29 member 1; SLC29A1. ENT1 hat eine Masse von 50.22kDa und eine Aminosäurelänge von 456.
Wir bieten 11 antikörper gegen ENT1, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).
Entrez Zusammenfassung
This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.
Gewebespezifität
Detected in erythrocytes (at protein level). Expressed in heart, brain, mammary gland, erythrocytes and placenta, and also in fetal liver and spleen.
Sequenzähnlichkeiten
Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
Posttranslationale Modifikation
Glycosylated.
Zellort
Basolateral cell membrane. Apical cell membrane. Cell membrane.
Predominantly localized in the basolateral membrane in polarized MDCK cells.
