eIF4E ist ein Gen, das durch das Symbol EIF4E kodiert wird. Andere Namen sind: Eukaryotic translation initiation factor 4E; eIF-4E; eIF-4F 25 kDa subunit; mRNA cap-binding proteinL1; EIF4F. eIF4E hat eine Masse von 25.1kDa, eine Aminosäurelänge von 217, und ist an Autism 19 beteiligt.
Wir bieten 19 antikörper gegen eIF4E, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus, Ratte und Affe.
Gen- und Proteininformationen
UniProt Zusammenfassung
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.
Entrez Zusammenfassung
The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants.
Rolle bei Krankheiten
Autism 19: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation.
Sequenzähnlichkeiten
Belongs to the eukaryotic initiation factor 4E family.
Posttranslationale Modifikation
Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex.
Zellort
Cytoplasm > P-body. Cytoplasm. Cytoplasm > Stress granule.
