EDG4 ist ein Gen, das durch das Symbol LPAR2 kodiert wird. Andere Namen sind: Lysophosphatidic acid receptor 2; LPA receptor 2; Lysophosphatidic acid receptor Edg-4; LPAR2; LPA2. EDG4 hat eine Masse von 39.08kDa und eine Aminosäurelänge von 351.
Wir bieten 7 antikörper gegen EDG4, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.
Entrez Zusammenfassung
This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined.
Gewebespezifität
Expressed most abundantly in testes and peripheral blood leukocytes with less expression in pancreas, spleen, thymus and prostate. Little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon.
Sequenzähnlichkeiten
Belongs to the G-protein coupled receptor 1 family.
Zellort
Cell surface. Cell membrane.
Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles.
