Dopamine Receptor D5 ist ein Gen, das durch das Symbol DRD5 kodiert wird. Andere Namen sind: D(1B) dopamine receptor; D(5) dopamine receptor; D1beta dopamine receptor; Dopamine D5 receptor; DRD5; DRD1B; DRD1L2. Dopamine Receptor D5 hat eine Masse von 52.95kDa, eine Aminosäurelänge von 477, und ist an Benign essential blepharospasm beteiligt.
Wir bieten 12 antikörper gegen Dopamine Receptor D5, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus, Ratte und Affe.
Gen- und Proteininformationen
UniProt Zusammenfassung
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
Entrez Zusammenfassung
This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2.
Gewebespezifität
Neuron-specific, localized primarily within limbic regions of the brain.
Rolle bei Krankheiten
Benign essential blepharospasm: A primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness.
Sequenzähnlichkeiten
Belongs to the G-protein coupled receptor 1 family.
