DOK5 ist ein Gen, das durch das Symbol DOK5 kodiert wird. Andere Namen sind: Docking protein 5; Downstream of tyrosine kinase 5; Insulin receptor substrate 6; IRS-6; C20orf180. DOK5 hat eine Masse von 35.46kDa und eine Aminosäurelänge von 306.
Wir bieten 6 antikörper gegen DOK5, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.
Entrez Zusammenfassung
The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants.
Gewebespezifität
Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.
Sequenzähnlichkeiten
Belongs to the DOK family. Type B subfamily.
Posttranslationale Modifikation
Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF.
