DNase I ist ein Gen, das durch das Symbol DNASE1 kodiert wird. Andere Namen sind: Deoxyribonuclease-1; Deoxyribonuclease I; DNASE1; DNL1; DRNI. DNase I hat eine Masse von 31.43kDa, eine Aminosäurelänge von 282, und ist an Systemic lupus erythematosus beteiligt.
Wir bieten 7 antikörper gegen DNase I, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ICC/IF and IP mit Proben abgeleitet von Human, Maus, Ratte und Rind.
Gen- und Proteininformationen
UniProt Zusammenfassung
Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:2251263, PubMed:11241278, PubMed:2277032). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (PubMed:11241278). Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity).
Entrez Zusammenfassung
This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Gewebespezifität
Principally in tissues of the digestive system. Highest levels found in urine, but also relatively abundant in semen and saliva.
Rolle bei Krankheiten
Systemic lupus erythematosus: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Sequenzähnlichkeiten
Belongs to the DNase I family.
Zellort
Secreted. Nucleus envelope.
Secretory protein, stored in zymogen granules and found in the nuclear envelope.
