DNA Polymerase iota ist ein Gen, das durch das Symbol POLI kodiert wird. Andere Namen sind: Eta2; RAD30 homolog B; POLI; RAD30B. DNA Polymerase iota hat eine Masse von 83.01kDa und eine Aminosäurelänge von 740.
Wir bieten 6 antikörper gegen DNA Polymerase iota, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Error-prone DNA polymerase specifically involved in DNA repair (PubMed:11013228, PubMed:11387224). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:11013228, PubMed:11387224, PubMed:14630940, PubMed:15199127). Favors Hoogsteen base-pairing in the active site (PubMed:15254543). Inserts the correct base with high-fidelity opposite an adenosine template (PubMed:15254543). Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine (PubMed:11013228). May play a role in hypermutation of immunogobulin genes (PubMed:12410315). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (PubMed:11251121, PubMed:14630940).
Entrez Zusammenfassung
The protein encoded by this gene is an error-prone DNA polymerase involved in DNA repair. The encoded protein promotes DNA synthesis across lesions in the template DNA, which other polymerases cannot do. The encoded polymerase inserts deoxynucleotides across lesions and then relies on DNA polymerase zeta to extend the nascent DNA strand to bypass the lesion.
Gewebespezifität
Ubiquitous. Highly expressed in testis.
Sequenzähnlichkeiten
Belongs to the DNA polymerase type-Y family.
Posttranslationale Modifikation
Monoubiquitinated. Protein monoubiquitination prevents POLI binding to ubiquitin via the ubiquitin-binding motif 1 and ubiquitin-binding motif 2.
Zellort
Nucleus.
Binding to ubiquitin mediates localization to replication forks after UV-induced DNA damage.
