Dkk3 ist ein Gen, das durch das Symbol DKK3 kodiert wird. Andere Namen sind: Dickkopf-related protein 3; Dickkopf-3; REIC. Dkk3 hat eine Masse von 38.39kDa und eine Aminosäurelänge von 350.
Wir bieten 10 antikörper gegen Dkk3, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Entrez Zusammenfassung
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein.
Gewebespezifität
Highest expression in heart, brain, and spinal cord.
Sequenzähnlichkeiten
Belongs to the dickkopf family.
Posttranslationale Modifikation
N- and O-glycosylated.
