DGAT1 ist ein Gen, das durch das Symbol DGAT1 kodiert wird. Andere Namen sind: Diacylglycerol O-acyltransferase 1; ACAT-related gene product 1; Acyl-CoA retinol O-fatty-acyltransferase; ARAT; Diglyceride acyltransferase; AGRP1; DGAT. DGAT1 hat eine Masse von 55.28kDa, eine Aminosäurelänge von 488, und ist an Diarrhea 7, protein-losing enteropathy type beteiligt.
Wir bieten 6 antikörper gegen DGAT1, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders.
Entrez Zusammenfassung
This gene encodes an multipass transmembrane protein that functions as a key metabolic enzyme. The encoded protein catalyzes the conversion of diacylglycerol and fatty acyl CoA to triacylglycerol. This enzyme can also transfer acyl CoA to retinol. Activity of this protein may be associated with obesity and other metabolic diseases.
Rolle bei Krankheiten
Diarrhea 7, protein-losing enteropathy type: A life-threatening disease characterized by severe, intractable, watery diarrhea.
Sequenzähnlichkeiten
Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
Zellort
Endoplasmic reticulum membrane.
