DFFB ist ein Gen, das durch das Symbol DFFB kodiert wird. Andere Namen sind: DNA fragmentation factor subunit beta; Caspase-activated deoxyribonuclease; CAD; Caspase-activated nuclease; CPAN; DNA fragmentation factor 40 kDa subunit; DFF-40; DFF2; DFF40. DFFB hat eine Masse von 39.11kDa und eine Aminosäurelänge von 338.
Wir bieten 6 antikörper gegen DFFB, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.
Entrez Zusammenfassung
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined.
Zellort
Cytoplasm. Nucleus.
