Decorin ist ein Gen, das durch das Symbol DCN kodiert wird. Andere Namen sind: Bone proteoglycan II; PG-S2; PG40; DCN; SLRR1B. Decorin hat eine Masse von 39.75kDa, eine Aminosäurelänge von 359, und ist an Corneal dystrophy, congenital stromal beteiligt.
Wir bieten 19 antikörper gegen Decorin, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus, Ratte, Rind, Schwein, Kaninchen, Huhn und Hund.
Gen- und Proteininformationen
UniProt Zusammenfassung
May affect the rate of fibrils formation.
Entrez Zusammenfassung
This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients.
Rolle bei Krankheiten
Corneal dystrophy, congenital stromal: A corneal dystrophy characterized by congenital corneal opacification consisting of a large number of flakes and spots throughout all layers of the stroma. It results in progressive, painless visual loss. Corneal erosions and photophobia are absent.
Sequenzähnlichkeiten
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
Posttranslationale Modifikation
The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.
Zellort
Secreted > Extracellular space > Extracellular matrix.
