DCK ist ein Gen, das durch das Symbol DCK kodiert wird. Andere Namen sind: Deoxycytidine kinase; Deoxyadenosine kinase; Deoxyguanosine kinase. DCK hat eine Masse von 30.52kDa und eine Aminosäurelänge von 260.
Wir bieten 12 antikörper gegen DCK, aufgewachsen in Kaninchen, Maus und Huhn, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine (PubMed:1996353, PubMed:12808445, PubMed:18377927, PubMed:19159229, PubMed:20614893). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents (PubMed:12808445).
Entrez Zusammenfassung
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.
Sequenzähnlichkeiten
Belongs to the DCK/DGK family.
Posttranslationale Modifikation
Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1.
