Cytokeratin 5 + 8 ist ein Gen, das durch das Symbol KRT8 kodiert wird. Andere Namen sind: Keratin, type II cytoskeletal 8; Cytokeratin-8; CK-8; Keratin-8; K8; Type-II keratin Kb8; KRT8; CYK8. Cytokeratin 5 + 8 hat eine Masse von 53.7kDa, eine Aminosäurelänge von 483, und ist an Cirrhosis beteiligt.
Wir bieten 7 antikörper gegen Cytokeratin 5 + 8, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus, Ratte, Rind, Schwein, Kaninchen, Schaf, Hund, Katze, Frettchen und Hamster.
Gen- und Proteininformationen
UniProt Zusammenfassung
Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Entrez Zusammenfassung
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
Gewebespezifität
Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
Rolle bei Krankheiten
Cirrhosis: A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension.
Sequenzähnlichkeiten
Belongs to the intermediate filament family.
Posttranslationale Modifikation
Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.
Zellort
Cytoplasm. Nucleus > Nucleoplasm. Nucleus matrix.
