Cytokeratin 18 ist ein Gen, das durch das Symbol KRT18 kodiert wird. Andere Namen sind: Keratin, type I cytoskeletal 18; Cell proliferation-inducing gene 46 protein; Cytokeratin-18; CK-18; Keratin-18; K18; KRT18; CYK18. Cytokeratin 18 hat eine Masse von 48.06kDa, eine Aminosäurelänge von 430, und ist an Cirrhosis beteiligt.
Wir bieten 73 antikörper gegen Cytokeratin 18, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus, Ratte, Rind, Schwein, Kaninchen, Affe, Schaf, Huhn, Hund, Katze, Frettchen, Goat, Hamster, Pferd, Säugetier und Zebrafisch.
Gen- und Proteininformationen
UniProt Zusammenfassung
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Entrez Zusammenfassung
KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.
Gewebespezifität
Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
Rolle bei Krankheiten
Cirrhosis: A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension.
Sequenzähnlichkeiten
Belongs to the intermediate filament family.
Posttranslationale Modifikation
Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.
Zellort
Cytoplasm > Perinuclear region. Nucleus > Nucleolus.
