Cyclophilin F ist ein Gen, das durch das Symbol PPIF kodiert wird. Andere Namen sind: Peptidyl-prolyl cis-trans isomerase F, mitochondrial; PPIase F; Cyclophilin D; CyP-D; Mitochondrial cyclophilin; CyP-M; Rotamase F; PPIF; CYP3. Cyclophilin F hat eine Masse von 22.04kDa und eine Aminosäurelänge von 207.
Wir bieten 6 antikörper gegen Cyclophilin F, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.
Entrez Zusammenfassung
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death.
Sequenzähnlichkeiten
Belongs to the cyclophilin-type PPIase family.
Posttranslationale Modifikation
Deacetylated at Lys-167 by SIRT3.
Zellort
Mitochondrion matrix.
