Cyclin E1 ist ein Gen, das durch das Symbol CCNE1 kodiert wird. Andere Namen sind: G1/S-specific cyclin-E1; CCNE1; CCNE. Cyclin E1 hat eine Masse von 47.08kDa und eine Aminosäurelänge von 410.
Wir bieten 25 antikörper gegen Cyclin E1, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Essential for the control of the cell cycle at the G1/S (start) transition.
Entrez Zusammenfassung
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB.
Gewebespezifität
Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.
Sequenzähnlichkeiten
Belongs to the cyclin family. Cyclin E subfamily.
Posttranslationale Modifikation
Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7.
