Cyclin C ist ein Gen, das durch das Symbol CCNC kodiert wird. Andere Namen sind: Cyclin-C; SRB11 homolog; hSRB11; CCNC. Cyclin C hat eine Masse von 33.24kDa und eine Aminosäurelänge von 283.
Wir bieten 9 antikörper gegen Cyclin C, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
Entrez Zusammenfassung
The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.
Sequenzähnlichkeiten
Belongs to the cyclin family. Cyclin C subfamily.
