Cyclin A2 ist ein Gen, das durch das Symbol CCNA2 kodiert wird. Andere Namen sind: Cyclin-A2; Cyclin-A; Cyclin A; CCNA2; CCN1; CCNA. Cyclin A2 hat eine Masse von 48.55kDa und eine Aminosäurelänge von 432.
Wir bieten 8 antikörper gegen Cyclin A2, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus, Ratte und Rind.
Gen- und Proteininformationen
UniProt Zusammenfassung
Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.
Entrez Zusammenfassung
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M.
Sequenzähnlichkeiten
Belongs to the cyclin family. Cyclin AB subfamily.
Posttranslationale Modifikation
Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.
Zellort
Nucleus. Cytoplasm.
Exclusively nuclear during interphase (PubMed:1312467). Detected in the nucleus and the cytoplasm at prophase (PubMed:1312467). Cytoplasmic when associated with SCAPER (PubMed:17698606).
