CtBP1 ist ein Gen, das durch das Symbol CTBP1 kodiert wird. Andere Namen sind: C-terminal-binding protein 1; CTBP. CtBP1 hat eine Masse von 47.54kDa, eine Aminosäurelänge von 440, und ist an Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome beteiligt.
Wir bieten 15 antikörper gegen CtBP1, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF, IP and ChIP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.
Entrez Zusammenfassung
This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants.
Gewebespezifität
Expressed in germinal center B-cells.
Rolle bei Krankheiten
Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome: An autosomal dominant disorder characterized by delayed motor development, intellectual disability, failure to thrive, hypotonia, ataxia, and tooth enamel defects.
Sequenzähnlichkeiten
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Posttranslationale Modifikation
The level of phosphorylation appears to be regulated during the cell cycle. Phosphorylation by HIPK2 on Ser-422 induces proteasomal degradation.
Zellort
Cytoplasm. Nucleus.
