Crk p38 ist ein Gen, das durch das Symbol CRK kodiert wird. Andere Namen sind: Adapter molecule crk; Proto-oncogene c-Crk; p38; CRK. Crk p38 hat eine Masse von 33.83kDa und eine Aminosäurelänge von 304.
Wir bieten 10 antikörper gegen Crk p38, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus, Ratte, Kaninchen, Affe und Hund.
Gen- und Proteininformationen
UniProt Zusammenfassung
Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1.
Entrez Zusammenfassung
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
Sequenzähnlichkeiten
Belongs to the CRK family.
Posttranslationale Modifikation
Phosphorylated on Tyr-221 upon cell adhesion. Results in the negative regulation of the association with SH2- and SH3-binding partners, possibly by the formation of an intramolecular interaction of phosphorylated Tyr-221 with the SH2 domain. This leads finally to the down-regulation of the Crk signaling pathway (PubMed:17515907). Isoform Crk-II: Phosphorylated by KIT (By similarity).
Zellort
Cytoplasm. Cell membrane.
Translocated to the plasma membrane upon cell adhesion.
