CRF1 ist ein Gen, das durch das Symbol CRHR1 kodiert wird. Andere Namen sind: Corticotropin-releasing factor receptor 1; CRF-R-1; Corticotropin-releasing hormone receptor 1; CRH-R-1; CRHR1; CRFR; CRFR1; CRHR. CRF1 hat eine Masse von 50.72kDa und eine Aminosäurelänge von 444.
Wir bieten 4 antikörper gegen CRF1, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
Entrez Zusammenfassung
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Naturally-occurring readthrough transcription between this gene and upstream GeneID:147081 results in transcripts that encode isoforms that share similarity with the products of this gene.
Gewebespezifität
Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe.
Sequenzähnlichkeiten
Belongs to the G-protein coupled receptor 2 family.
Posttranslationale Modifikation
C-terminal Ser or Thr residues may be phosphorylated.
Zellort
Cell membrane. Endosome.
Agonist-binding promotes endocytosis.