CREM ist ein Gen, das durch das Symbol CREM kodiert wird. Andere Namen sind: cAMP-responsive element modulator; Inducible cAMP early repressor; ICER. CREM hat eine Masse von 37.01kDa und eine Aminosäurelänge von 345.
Wir bieten 6 antikörper gegen CREM, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550).
Entrez Zusammenfassung
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.
Gewebespezifität
Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.
Sequenzähnlichkeiten
Belongs to the bZIP family.
Posttranslationale Modifikation
Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome.
