CRABP2 ist ein Gen, das durch das Symbol CRABP2 kodiert wird. Andere Namen sind: Cellular retinoic acid-binding protein 2; Cellular retinoic acid-binding protein II; CRABP-II. CRABP2 hat eine Masse von 15.69kDa und eine Aminosäurelänge von 138.
Wir bieten 9 antikörper gegen CRABP2, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF and ChIP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
Entrez Zusammenfassung
This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
Sequenzähnlichkeiten
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Posttranslationale Modifikation
Sumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent nuclear translocation.
Zellort
Cytoplasm. Endoplasmic reticulum. Nucleus.
Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.
