Corticotropin Releasing Factor ist ein Gen, das durch das Symbol CRH kodiert wird. Andere Namen sind: Corticoliberin; Corticotropin-releasing factor; CRF; Corticotropin-releasing hormone; CRH. Corticotropin Releasing Factor hat eine Masse von 21.42kDa und eine Aminosäurelänge von 196.
Wir bieten 9 antikörper gegen Corticotropin Releasing Factor, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).
Entrez Zusammenfassung
This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition.
Gewebespezifität
Produced by the hypothalamus and placenta.
Sequenzähnlichkeiten
Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
