CLEC12A ist ein Gen, das durch das Symbol CLEC12A kodiert wird. Andere Namen sind: C-type lectin domain family 12 member A; C-type lectin-like molecule 1; CLL-1; Dendritic cell-associated lectin 2; DCAL-2; Myeloid inhibitory C-type lectin-like receptor; MICL; CLL1; DCAL2. CLEC12A hat eine Masse von 30.76kDa und eine Aminosäurelänge von 265.
Wir bieten 6 antikörper gegen CLEC12A, aufgewachsen in Kaninchen, Ziege und Human, welche geeignet sind für WB, IHC, ELISA and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
Entrez Zusammenfassung
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13.
Gewebespezifität
Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages.
Posttranslationale Modifikation
Highly N-glycosylated. Glycosylation varies between cell types.
Zellort
Cell membrane.
Ligand binding leads to internalization.
