Claudin 6 ist ein Gen, das durch das Symbol CLDN6 kodiert wird. Andere Namen sind: Claudin-6; Skullin; CLDN6. Claudin 6 hat eine Masse von 23.29kDa und eine Aminosäurelänge von 220.
Wir bieten 13 antikörper gegen Claudin 6, aufgewachsen in Kaninchen und Human, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Plays a major role in tight junction-specific obliteration of the intercellular space.
Entrez Zusammenfassung
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.
Gewebespezifität
Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.
Sequenzähnlichkeiten
Belongs to the claudin family.
Zellort
Cell junction > Tight junction. Cell membrane.
