Claudin 4 ist ein Gen, das durch das Symbol CLDN4 kodiert wird. Andere Namen sind: Claudin-4; Clostridium perfringens enterotoxin receptor; CPE-R; Williams-Beuren syndrome chromosomal region 8 protein; CLDN4; CPER; CPETR1; WBSCR8. Claudin 4 hat eine Masse von 22.08kDa und eine Aminosäurelänge von 209.
Wir bieten 12 antikörper gegen Claudin 4, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Entrez Zusammenfassung
The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.
Sequenzähnlichkeiten
Belongs to the claudin family.
Posttranslationale Modifikation
Phosphorylated. Phosphorylation by EPHA2 is stimulated by EFNA1 and alters interaction with TJP1.
Zellort
Cell junction > Tight junction. Cell membrane.
CLDN4 is required for tight junction localization in the kidney.
