Clathrin light chain ist ein Gen, das durch das Symbol CLTA kodiert wird. Andere Namen sind: Clathrin light chain A; Lca; CLTA. Clathrin light chain hat eine Masse von 27.08kDa und eine Aminosäurelänge von 248.
Wir bieten 9 antikörper gegen Clathrin light chain, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582).
Entrez Zusammenfassung
Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12.
Sequenzähnlichkeiten
Belongs to the clathrin light chain family.
Zellort
Cytoplasmic vesicle membrane. Membrane > Coated pit. Cytoplasm > Cytoskeleton > Spindle.
Cytoplasmic face of coated pits and vesicles. In complex with TACC3 and CKAP5 (forming the TACC3/ch-TOG/clathrin complex) localized to inter-microtubule bridges in mitotic spindles.
