CES2 ist ein Gen, das durch das Symbol CES2 kodiert wird. Andere Namen sind: Cocaine esterase; Carboxylesterase 2; CE-2; Methylumbelliferyl-acetate deacetylase 2; ICE. CES2 hat eine Masse von 61.81kDa und eine Aminosäurelänge von 559.
Wir bieten 6 antikörper gegen CES2, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443). Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443). Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105).
Entrez Zusammenfassung
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.
Gewebespezifität
Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum.
Sequenzähnlichkeiten
Belongs to the type-B carboxylesterase/lipase family.
Posttranslationale Modifikation
Glycosylated.
Zellort
Endoplasmic reticulum lumen.
