CEACAM5 ist ein Gen, das durch das Symbol CEACAM5 kodiert wird. Andere Namen sind: Carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen; CEA; Meconium antigen 100. CEACAM5 hat eine Masse von 76.8kDa und eine Aminosäurelänge von 702.
Wir bieten 76 antikörper gegen CEACAM5, aufgewachsen in Kaninchen, Maus, Ziege und Human, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC, IP and RIA mit Proben abgeleitet von Human, Maus, Ratte und Affe.
Gen- und Proteininformationen
UniProt Zusammenfassung
Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).
Entrez Zusammenfassung
This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants.
Gewebespezifität
Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
Sequenzähnlichkeiten
Belongs to the immunoglobulin superfamily. CEA family.
Posttranslationale Modifikation
Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.
Zellort
Cell membrane. Apical cell membrane. Cell surface.
Localized to the apical glycocalyx surface.
