CDK10 ist ein Gen, das durch das Symbol CDK10 kodiert wird. Andere Namen sind: Cyclin-dependent kinase 10; Cell division protein kinase 10; Serine/threonine-protein kinase PISSLRE. CDK10 hat eine Masse von 41.04kDa, eine Aminosäurelänge von 360, und ist an Al Kaissi syndrome beteiligt.
Wir bieten 7 antikörper gegen CDK10, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC and ELISA mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (PubMed:24218572). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling (PubMed:27104747).
Entrez Zusammenfassung
The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene.
Rolle bei Krankheiten
Al Kaissi syndrome: An autosomal recessive developmental disorder characterized by growth retardation, spine malformation, facial dysmorphisms, and developmental delay.
Sequenzähnlichkeiten
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Zellort
Cytoplasm > Cytoskeleton > Cilium basal body.
