Cdc6 ist ein Gen, das durch das Symbol CDC6 kodiert wird. Andere Namen sind: Cell division control protein 6 homolog-related protein; Cdc18-related protein; HsCdc18; p62(cdc6); HsCDC18L. Cdc6 hat eine Masse von 62.72kDa, eine Aminosäurelänge von 560, und ist an Meier-Gorlin syndrome 5 beteiligt.
Wir bieten 10 antikörper gegen Cdc6, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF, IP and ChIP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
Entrez Zusammenfassung
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.
Rolle bei Krankheiten
Meier-Gorlin syndrome 5: A syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.
Sequenzähnlichkeiten
Belongs to the CDC6/cdc18 family.
Zellort
Nucleus. Cytoplasm.
The protein is nuclear in G1 and cytoplasmic in S-phase cells (PubMed:9566895).
