CDC5L ist ein Gen, das durch das Symbol CDC5L kodiert wird. Andere Namen sind: Cell division cycle 5-like protein; Cdc5-like protein; Pombe cdc5-related protein; KIAA0432; PCDC5RP. CDC5L hat eine Masse von 92.25kDa und eine Aminosäurelänge von 802.
Wir bieten 6 antikörper gegen CDC5L, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA and FC mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28502770, PubMed:28076346, PubMed:29361316, PubMed:29360106, PubMed:29301961, PubMed:30728453, PubMed:30705154). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811).
Entrez Zusammenfassung
The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing.
Gewebespezifität
Ubiquitously expressed in both fetal and adult tissues.
Sequenzähnlichkeiten
Belongs to the CEF1 family.
Posttranslationale Modifikation
Phosphorylated on serine and threonine residues. Phosphorylation on Thr-411 and Thr-438 is required for CDC5L-mediated mRNA splicing. Has no effect on subcellular location nor on homodimerization. Phosphorylated in vitro by CDK2. Phosphorylation enhances interaction with PPP1R8.
Zellort
Nucleus. Nucleus speckle. Cytoplasm.
May shuttle between cytoplasm and nucleus.
