Cdc37 ist ein Gen, das durch das Symbol CDC37 kodiert wird. Andere Namen sind: Hsp90 co-chaperone Hsp90 chaperone protein kinase-targeting subunit; p50CDC37A. Cdc37 hat eine Masse von 44.47kDa und eine Aminosäurelänge von 378.
Wir bieten 14 antikörper gegen Cdc37, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus, Ratte und S. cerevisiae.
Gen- und Proteininformationen
UniProt Zusammenfassung
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206).
Entrez Zusammenfassung
The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases.
Sequenzähnlichkeiten
Belongs to the CDC37 family.
Posttranslationale Modifikation
Constitutively sumoylated by UBE2I.
