Cdc27 ist ein Gen, das durch das Symbol CDC27 kodiert wird. Andere Namen sind: Cell division cycle protein 27 homolog; Anaphase-promoting complex subunit 3; APC3 homologHs; H-NUC; ANAPC3; D0S1430E; D17S978E. Cdc27 hat eine Masse von 91.87kDa und eine Aminosäurelänge von 824.
Wir bieten 8 antikörper gegen Cdc27, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Entrez Zusammenfassung
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y.
Sequenzähnlichkeiten
Belongs to the APC3/CDC27 family.
Posttranslationale Modifikation
Phosphorylated. Phosphorylation on Ser-426 and Thr-446 occurs specifically during mitosis.
