Cdc23 ist ein Gen, das durch das Symbol CDC23 kodiert wird. Andere Namen sind: Cell division cycle protein 23 homolog; Anaphase-promoting complex subunit 8; APC8; Cyclosome subunit 8; ANAPC8. Cdc23 hat eine Masse von 68.83kDa und eine Aminosäurelänge von 597.
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Gen- und Proteininformationen
UniProt Zusammenfassung
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Entrez Zusammenfassung
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.
Sequenzähnlichkeiten
Belongs to the APC8/CDC23 family.
Posttranslationale Modifikation
Phosphorylated. Phosphorylation on Thr-562 occurs specifically during mitosis.
