CD62L ist ein Gen, das durch das Symbol SELL kodiert wird. Andere Namen sind: L-selectin; CD62 antigen-like family member L; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; Lymph node homing receptor; TQ1; gp90-MEL; SELL; LNHR; LYAM1. CD62L hat eine Masse von 42.19kDa und eine Aminosäurelänge von 372.
Wir bieten 33 antikörper gegen CD62L, aufgewachsen in Kaninchen, Maus und Ratte, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus, Ratte, Rind, Schaf und Hund.
Gen- und Proteininformationen
UniProt Zusammenfassung
Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28489325, PubMed:28011641). Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641).
Entrez Zusammenfassung
This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene.
Gewebespezifität
Expressed in B-cell lines and T-lymphocytes.
Sequenzähnlichkeiten
Belongs to the selectin/LECAM family.
Posttranslationale Modifikation
N-glycosylated.
