CD53 ist ein Gen, das durch das Symbol CD53 kodiert wird. Andere Namen sind: Leukocyte surface antigen Cell surface glycoprotein Tetraspanin-25; Tspan-25; MOX44; TSPAN25. CD53 hat eine Masse von 24.34kDa und eine Aminosäurelänge von 219.
Wir bieten 12 antikörper gegen CD53, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity).
Entrez Zusammenfassung
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants.
Gewebespezifität
B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes and peripheral T-cells.
Sequenzähnlichkeiten
Belongs to the tetraspanin (TM4SF) family.
Zellort
Cell membrane. Cell junction. Membrane.
Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes.
